KPMP: Kidney Precision Medicine Project

what is the KPMP?

The Kidney Precision Medicine Project (KPMP) is an ambitious, multi-year project funded by the NIDDK with the purpose of understanding and finding new ways to treat chronic kidney disease (CKD) and acute kidney injury (AKI).

BACKGROUND

Acute kidney injury (AKI) and chronic kidney disease (CKD) impose a significant global health burden. Yet, no effective therapies currently exist for AKI, and only a few are available for CKD. Historically, AKI and CKD have been described as single, uniform diseases. However, growing consensus suggests that different disease pathways lead to different subgroups of AKI and CKD (AKIs and CKDs).

Access to human kidney biopsy tissue is a critical first step to define disease heterogeneity and determine the precise molecular pathways that will facilitate identification of specific drug targets and ultimately enable individualized care for people with AKI and CKD.

KRI INVOLVEMENT

Former KRI Director, Jonathan Himmelfarb, serves as the contact PI for the multi-PI Central Hub. The Kidney Research Institute serves as the Administrative Core (AC) of the Central Hub, with Jonathan Himmelfarb and current KRI Director Ian de Boer serving as co-directors of the core.

Responsibilities of the Administrative Core include:

• Administrative and meeting support
• Establishing working groups and consortium organization
• Ensuring patient input is requested, received, and implemented 
• Managing the Opportunity Pool to form new partnerships

Who should I contact for more information?

Ian de Boer
deboer@uw.edu