KPMP: Kidney Precision Medicine Project
Petter Bjornstad, MD
Ian de Boer, MD
What is the KPMP?
The Kidney Precision Medicine Project (KPMP) is an ambitious, multi-year initiative funded by the NIDDK to research and develop novel approaches to treat chronic kidney disease (CKD) and acute kidney injury (AKI).
Understanding the need for the Kidney Precision Medicine Project
Acute kidney injury (AKI) and chronic kidney disease (CKD) impose a significant global health burden. Yet, no effective therapies currently exist for AKI, and only a few are available for CKD. Historically, researchers have described AKI and CKD as single, uniform diseases. However, a growing consensus suggests that different disease pathways lead to subgroups of AKIs and CKDs.
Access to human kidney biopsy tissue is a critical first step in defining disease heterogeneity and determining the precise molecular pathways that will facilitate the identification of specific drug targets, ultimately enabling individualized care for people with AKI and CKD.
KPMP & Type 1 Diabetes
Over 1.4 million Americans live with type 1 diabetes (T1D), a number projected to reach 2 million by 2030, with approximately one-third developing chronic kidney disease (CKD) that significantly increases their risk of cardiovascular disease and premature death.
The University of Washington KPMP T1D Recruitment Site will contribute to the KPMP by studying people with type 1 diabetes (T1D). The goal is to determine why many people with T1D get CKD, understand the molecular mechanisms involved for individuals, and pave the way for new approaches to prevent and treat CKD. Volunteers with T1D will undergo a standardized KPMP kidney biopsy along with other studies to see how T1D affects the body, including detailed eye and kidney imaging.
KRI INVOLVEMENT
Many KRI investigators are active in the studies.
- Charles Alpers, MD
- Pavan Bhatraju, MD, MSc
- Andrew Hoofnagle, MD, PhD
- Ashley Jefferson, MD
- Bryan Kestenbaum, MD, MS
- Chistine Limonte, MD
- Behzad Najafian, MD
- Kasra Rezaei, MD
- Kalie Tommerdahl, MD
- Katherine Tuttle, MD
- Ricky Wang, PhD
- Bessie Young, MD, MPH
- Leila Zelnick, PhD
- and others
Administrative Core
Former KRI Director Jonathan Himmelfarb, MD, serves as the contact PI for the multi-PI Central Hub.
Responsibilities of the Administrative Core:
- Administrative and meeting support
- Establish working groups and a consortium organization
- Request, receive, and implement patient input
- Manage the opportunity pool to form new partnerships
Who should I contact for more information?
Petter Bjornstad, MD
Email: pettermb@uw.edu
Ian de Boer, MD
Email: deboer@uw.edu