Katherine R.

Tuttle

MD

FASN

FACP

FNKF

Contact

Providence Medical Research Center, Providence Health Care
105 W. 8th Avenue
Suite 250E
Spokane, WA 99204

P: 509-474-4345
F: 509-474-4325
E: katherine.tuttle@providence.org

About

Katherine R. Tuttle, MD, FASN, FACP, FNKF, is Executive Director for Research at Providence Inland Northwest Health, Regional Principal Investigator of the Institute of Translational Health Sciences, and Professor of Medicine at the University of Washington. She oversees a regional network of 17 clinical research centers and chairs the research Regional Executive Council for the University of Washington. Dr. Tuttle earned her medical degree and completed her residency in Internal Medicine at Northwestern University in Chicago. She was a fellow in Metabolism and Endocrinology at Washington University in St. Louis. Her Nephrology fellowship training was performed at the University of Texas Health Science Center in San Antonio.

Dr. Tuttle’s major research interests are in diabetes and chronic kidney disease. As a clinical and translational scientist, she has published over 400 original peer-reviewed articles. Early in her career, her first independently awarded research grant produced a landmark study elucidating physiological principles underlying glomerular hyperfiltration in humans with diabetes. This foundational work led to a number of subsequent physiological and pre-clinical studies that laid a foundation for new therapeutic targets in clinical trials. She has seen that work to the finish line over more than three decades to help deliver SGLT2 inhibition as a highly impactful therapy to reduce risks of kidney failure, cardiovascular events, and death in persons with and without diabetes. Dr. Tuttle has also been a leading investigator across the translational arc for other breakthrough therapies, including incretins and anti-inflammatory agents. She led an original clinical trial that elevated glucagon-like peptide-1 receptor agonists to therapeutics for chronic kidney disease. An agent in this class has since been proven to improve kidney, cardiovascular, and survival outcomes for persons with type 2 diabetes and chronic kidney disease. She leads the Center for Kidney Disease Research, Education and Hope (CURE-CKD) Registry of real-world data for chronic kidney disease, diabetes, prediabetes, and hypertension from over 6 million health system patients. In sum, her collective work has shaped the “pillars of therapy“ approach to chronic kidney disease in a most fundamental manner across the spectrum of scientific discovery, clinical trials, and population-level implementation.

Dr. Tuttle is Chair of the Diabetic Kidney Disease Collaborative for the American Society of Nephrology. She served on the inaugural Board of Directors for the Kidney Health Initiative and has chaired numerous working groups and committees for organizations including the National Institutes of Health, the American Society of Nephrology, the International Society of Nephrology, Kidney Disease Improving Global Outcomes, the National Kidney Foundation, and the American Diabetes Association. Dr. Tuttle has received many honors and awards including the John P. Peters Lifetime Achievement Award from the American Society of Nephrology, the Medal of Excellence from the American Association of Kidney Patients, the Garabed Eknoyan Award from the National Kidney Foundation, the YWCA Woman of Achievement Award in Science, and two University of Washington Outstanding Clinical Faculty Awards.

Education and Training

Endocrinology and Metabolism Fellowship
Washington University
St. Louis, MO

Nephrology Fellowship
University of Texas Health Sciences Center
San Antonio, TX

Medical Residency
Northwestern University Medical School
Chicago, IL

Medical School
Northwestern University Medical School
Chicago, IL

Research Interests

• Clinical and translational science for diabetes and chronic kidney disease
• Diabetic kidney disease: cellular and molecular mechanisms, clinical research in novel therapeutic agents
• Nutrition: Cellular and molecular mechanisms of dietary protein-induced kidney damage, clinical research on optimal dietary interventions
• Hypertension: clinical research in defining selection of therapeutic combinations
• Renal vascular disease: A randomized clinical trial of medical versus interventional strategy

PUBLICATIONS