PANDA
Investigators
WHAT IS THE PANDA STUDY?
The Pathogenesis of Kidney Disease in Type 1 Diabetes: A Modern Kidney Biopsy Cohort (PANDA Study) is an observational study. It aims to define the clinical, structural, and molecular features of kidney disease in the modern era of treatment for type 1 diabetes (T1D). About one-third of patients with T1D develop kidney disease, which can lead to kidney failure and accelerate other diabetes complications, like cardiovascular disease. The ultimate goal of the PANDA study is to identify new and better ways to prevent, diagnose, and treat kidney disease for people with T1D. The PANDA study is being done at two sites – the University of Washington and the University of Colorado. The central activity is a kidney biopsy performed at enrollment, which is used for advanced new studies to assess kidney structure and function.
WHAT ARE THE GOALS OF THE STUDY?
- To determine how T1D affects metabolism in the cells of the kidney.
- To determine how metabolism in the cells of the kidney correlates with kidney structure, assessed by histopathology.
- To assess how metabolism in the cells of the kidney changes over time in T1D
WHO CAN JOIN THE STUDY?
Most anyone who has had T1D for 5 years or more can participate. It is not necessary to have kidney disease. Full eligibility criteria are assessed at screening to make sure that a kidney biopsy is safe.
WHAT DO I DO ONCE I’VE ENROLLED?
- Blood and urine tests at enrollment and yearly thereafter
- Kidney MRI and DEXA scan at enrollment
- Kidney biopsy at enrollment
WHO DO I CONTACT FOR MORE INFORMATION?
Clinical Research Coordinators
Ramya Ravichandran
drmia@Nephrology.washington.edu
Melissa Leroux
lerouxm@uw.edu
