CONCORD: Combination of Novel Therapies for CKD Comorbid Depression

This study is being done to find out whether treatment of major depression with the medication, Bupropion, Behavioral Activation Teletherapy (BAT), both, Clinical Management (CM) and/or placebo will improve depression, quality of life and overall functioning in CKD patients. The secondary purpose is to find out whether CKD patients will be able to tolerate these treatments.