This is unpublished

Cellular and Molecular Mechanisms of COVID-19 Mediated Kidney Injury

Covid 19 virus

Jonathan Himmelfarb, MD

Completed Studies
AKI
Laboratory Studies
Pinned
Principal Investigator
Jonathan Himmelfarb
Funding Agency
NCATS
Status
Completed

What is the study?

Using our ‘human kidney-on-a-chip’ microphysiological systems (MPS), this project aims to better understand the mechanisms of kidney involvement in COVID-19 infection to foster the development of effective therapies beyond supportive care.

What are the goals of the study?

We aim to:

  1. Characterize SARS-CoV-2 (COVID-19) receptor expression, binding, engagement, and modulation in kidney proximal tubular epithelial cells, podocytes, and microvascular endothelial cells within the human kidney and vascular MPS, and
  2. Assess SARS-CoV-2 (COVID-19) candidate therapeutics including recombinant ACE 2, DPP-4 inhibitors, and angiopoietin 1 hyper-signaling constructs for the ability to block kidney-specific cellular uptake of SARS-CoV-2 (COVID-19) and/or alter downstream signaling and injury phenotypes within human kidney and vascular MPS.