This is unpublished

Cellular and Molecular Mechanisms of COVID-19 Mediated Kidney Injury

Jonathan Himmelfarb, MD

Completed Studies
AKI
Laboratory Studies
Pinned
Principal Investigator
Jonathan Himmelfarb
Funding Agency
NCATS
Status
Completed

What is the study?

Using our ‘human kidney-on-a-chip’ microphysiological systems (MPS), this project aims to better understand the mechanisms of kidney involvement in COVID-19 infection to foster the development of effective therapies beyond supportive care.

What are the goals of the study?

We aim to:

  1. Characterize SARS-CoV-2 (COVID-19) receptor expression, binding, engagement, and modulation in kidney proximal tubular epithelial cells, podocytes, and microvascular endothelial cells within the human kidney and vascular MPS, and
  2. Assess SARS-CoV-2 (COVID-19) candidate therapeutics including recombinant ACE 2, DPP-4 inhibitors, and angiopoietin 1 hyper-signaling constructs for the ability to block kidney-specific cellular uptake of SARS-CoV-2 (COVID-19) and/or alter downstream signaling and injury phenotypes within human kidney and vascular MPS.