PEOPLE > Thomas M. Coffman, M.D.
Thomas M. Coffman, M.D.
James R. Clapp Professor of Medicine in the School of Medicine
Chief, Division of Nephrology
Senior Vice-chair for Academic Affairs, Department of Medicine, Duke University Medical Center
Duke University Medical Center
Durham, NC 27710
Education and Training
MD, Ohio State University College of Medicine, 1980
Medicine, Duke University Medical Center, 1980-1983
Nephrology, Duke University Medical Center, 1983-1985
My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension. (from Duke Nephrology website).
Facemire, CS; Griffiths, R; Audoly, LP; Koller, BH; Coffman, TM. The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background. Hypertension. 2010;55:531-538.
Gurley, SB; Mach, CL; Stegbauer, J; Yang, J; Snow, KP; Hu, A; Meyer, TW; Coffman, TM. Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice. American Journal of Physiology: Renal Physiology. 2010;298:F788-F795.
Benigni, A; Corna, D; Zoja, C; Sonzogni, A; Latini, R; Salio, M; Conti, S; Rottoli, D; Longaretti, L; Cassis, P; Morigi, M; Coffman, TM; Remuzzi, G. Disruption of the Ang II type 1 receptor promotes longevity in mice. Journal of Clinical Investigation. 2009;119:524-530.
Crowley, SD; Vasievich, MP; Ruiz, P; Gould, SK; Parsons, KK; Pazmino, AK; Facemire, C; Chen, BJ; Kim, HS; Tran, TT; Pisetsky, DS; Barisoni, L; Prieto-Carrasquero, MC; Jeansson, M; Foster, MH; Coffman, TM. Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis. Journal of Clinical Investigation. 2009;119:943-953.
Facemire, CS; Nixon, AB; Griffiths, R; Hurwitz, H; Coffman, TM. Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression. Hypertension. 2009;54:652-658.
Coffman, TM; Crowley, SD. Kidney in hypertension: guyton redux. Hypertension. 2008;51:811-816.