PEOPLE > Ronald J. Falk, M.D.
Ronald J. Falk, M.D.
Allan Brewster Distinguished Professor of Medicine; Chief, Division of Nephrology and Hypertension; Director, UNC Kidney Center
Education and Training
BA Cum Laude: Dartmouth College, 1973
MD: University of North Carolina, 1977
Resident: University of North Carolina, 1977
Resident: University of North Carolina, 1978-80
Nephrology Fellow: University of North Carolina, 1980-1
Pediatric Nephrology Research Fellow: University of Minnesota, 1981-4
Research Interests
Dr. Falk's research probes questions focused on immune mediated kidney diseases, especially glomerulonephritis. His clinical and basic science interests include both ANCA glomerulonephritis and small vessel vasculitis (SVV). A central objective of Falk's research is elucidating the causes of ANCA necrotizing and crescentic glomerulonephritis. Unraveling the cause of this disease requires considering a number of factors involved in the devolpment of ANCA glomerulonephritis. Falk conceptualizes this process as opening the vasculitis lock with a key that has a number of "ridges and valleys" analogous to those factors that contribute to the development of this autoimmune disease.
Dr. Falk participates in a research group that, in a large study over the last four years has revealed a number of avenues of investigation and new approaches to ongoing questions that pertain not only to ANCA glomerulonephritis, but to the general fields of autoimmunity, inflammation and basic neutrophil and monocyte biology.
SELECTED PUBLICATIONS
Pendergraft III, WF, Preston, GA, Shah R R, Tropsha, A, Jennette, JC, Falk, RJ cPR3105-206, a protein complementary to the human autoantigen Proteinase 3, triggers autoimmunity. Nat Med 10(1):72-79, 2004.
Falk RJ. Treatment of lupus nephritis: work in progress (editorial). N Engl J Med 343(16):1182-3, 2000.
Jennette JC , Falk RJ: Small Vessel Vasculitis. N Engl J Med 338:994, 1998.
Falk RJ, Scheinman J, Phillips G, Orringer E, Johnson A, and Jennette JC: Prevalence and pathologic features of sickle cell nephropathy and response to inhibition of angiotensin-converting enzyme. N Engl J Med 326:910-915, 1992.
Falk RJ, Terrell RS, Charles LA, Jennette JC: Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci, U.S.A. 87:4115-4119,1990.
Falk RJ, Jennette JC: Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 318:1651-1657, 1988.