PEOPLE > Nancy J. Brown, M.D.

Nancy J. Brown, M.D.

Robert H. Williams Professor of Medicine
Dean, Yale School of Medicine

Education and Training

Research Interests

Research in our laboratory focuses on the following areas:
1. Role of the renin-angiotensin-aldosterone system in modulating oxidative stress, inflammation and fibrinolysis.

2. Role of the renin-angiotensin-aldosterone system in regulating glucose homeostasis.

3. Cardiovascular effects of the kallikrein-kinin system.

4. Role of arachidonic acid monooxygenases and epoxygenases in the regulation of blood pressure and cardiovascular risk.

5. Contribution of peptidases to angiotensin-converting enzyme (ACE) inhibitor-associated angioedema.

6. Pharmacogenetics of the renin-angiotensin-aldosterone and kallikrein-kinin sytems.

SELECTED PUBLICATIONS

Marney AM, Ma J, Luther JM, Ikizler TA, Brown NJ. Endogenous bradykinin contributes to increased plasminogen activator inhibitor 1 antigen following hemodialysis. J.Am.Soc.Nephrol. 2009 Oct;20(10):2246-52. PMCID:PMC2754101

Adam A, Montpas N, Keire D, Desormeaux A, Brown NJ, Marceau F, Westenberger B. Bradykinin forming capacity of oversulfated chondroitin sulfate contaminated heparin in vitro. Biomaterials 2010 Aug;31(22):5741-8. PMCID:PMC2896062

Billings FT, Pretorius M, Siew ED, Yu C, Brown NJ. Early postoperative statin therapy is associated with a lower incidence of acute kidney injury after cardiac surgery. J.Cardiothorac.Vasc.Anesth. 2010 Dec;24(6):913-20. PMCID:PMC2992577

Chan KE, Ikizler TA, Gamboa JL, Yu C, Hakim RM, Brown NJ. Combined angiotensin-converting enzyme inhibition and receptor blockade associate with increased risk of cardiovascular death in hemodialysis patients. Kidney Int 2011 Nov;80(9):978-85

Gamboa JL, Pretorius M, Todd-Tzanetos DR, Luther JM, Yu C, Ikizler TA, Brown NJ. Comparative effects of angiotensin-converting enzyme inhibition and angiotensin-receptor blockade on inflammation during hemodialysis. J.Am.Soc.Nephrol. 2012 Feb;23(2):334-42. PMCID:PMC3269170

Billings FT, Pretorius M, Schildcrout JS, Mercaldo ND, Byrne JG, Ikizler TA, Brown NJ. Obesity and oxidative stress predict AKI after cardiac surgery. J.Am.Soc.Nephrol. 2012 Jul;23(7):1221-8. PMCID:PMC3380645