PEOPLE > Mark Wurfel, M.D., Ph.D.

Mark Wurfel, M.D., Ph.D.

Professor of Medicine, Pulmonary, Critical Care and Sleep Medicine;
Endowed Professorship, DEPARTMENT - Pulmonary, Critical Care and Sleep Medicine

Education and Training

Research Interests

Our laboratory is interested in the mechanisms underlying susceptibility to organ dysfunction and death in the setting of severe infection and injury. In particular we are currently performing studies directed at identifying genetic loci that contribute to acute lung injury and acute kidney injury in the setting of sepsis and trauma using genome-wide approaches. We are also using next-generation sequencing approaches to identify low frequency exonic variants that contribute to the severity of acute lung injury. On a more basic level we are interested in the identification of genetic loci that modulate gene expression during an innate immune inflammatory response.

SELECTED PUBLICATIONS

Wurfel MM, Park WY, Radella F, Ruzinski J, Sandstrom A, Strout J, Bumgarner RE, Martin TR. Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity. J. Immunol. 2005;175:2570-2578.

Storey JD, Madeoy J, Strout JL, Wurfel MM, Ronald J, Akey JM. Gene-expression variation within and among human populations. Am J Hum Genet 2007;80:502-509.

Wurfel MM, Gordon AC, Holden T, Radella F, Strout J, Kajikawa O, Ruzinski J, Rona G, Black RA, Stratton S, Jarvik GP, Hajjar AM., Nickerson DA., Rieder M, Sevransky J, Maloney JP., Moss M, Martin G, Shanholtz C, Garcia JGN, Gao L, Brower R, Barnes KC, Walley KR, Russell JA, Martin TR. TLR1 polymorphisms affects innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med. 2008; 178(7):710-720.

Ko DC, Shukla KP, Fong C, Wasnick M, Brittnacher MJ, Wurfel MM, Holden TD, O'Keefe GE, Van Yserloo B, Akey JM, Miller SI. A Genome-wide In Vitro Bacterial-Infection Screen Reveals Human Variation in the Host Response Associated with Inflammatory Disease. Am J Hum Genet. 2009 Aug 5(2):214-27. Epub 2009 Aug 6.

Glavan BJ, Holden TD, Goss CH, Black RA, Martin TR, Wurfel MM, & ARDSnet Investigators. Genetic variation in the FAS gene and associations with acute lung injury. Am J Respir Crit Care Med. 2010; In Press.