PEOPLE > John D. Scott, Ph.D.
John D. Scott, Ph.D.
Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology at the Howard Hughes Medical Institute;
Chair, Department of Pharmacology at University of Washington;
Professor and Chair, Provost, School of Medicine
University of Washington School of Medicine
Department of Pharmacology
1959 NE Pacific St.
Seattle, WA 98195
Education and Training
B.Sc. (Hons) in Biochemistry
University of Aberdeen,
John Scott is interested in the specificity of signal transduction events that are controlled by anchoring proteins, which facilitate rapid signal transduction by optimally positioning protein kinases and phosphatases in the vicinity of their activating signals and close to their substrates.
Whiting, J.L., Ogier, L., Forbush, K., Bucko, P., Gopalan, J., Seternes, O.M., Langeberg, L.K., and Scott, J.D. (2016) AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Proc Natl Acad Sci U S A. 113:E4328-E4337. PMCID: PMC4968721.
Smith, F.D., Esseltine, J.L., Nygren, P.J., Vessler, D., Byrne, D.P., Vonderach, M., Strashnov, I., Eyers, C.E., Eyers, P.A., Langeberg, L.K., and Scott, J.D. (2017) Local protein kinase A action proceeds through intact holoenzymes. Science. 356:1288-1293. PMCID: PMC5693252
Nygren, P.J., Mehta, S., Schweppe, D.K., Langeberg, L.K., Whiting, J.L., Weisbrod, C.R., Bruce, J.E., Zhang, J., Veesler, D., and Scott, J.D. (2017) Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. eLife. 6:e30872 doi: 10.7554/eLife.30872 epub AOP Oct 2, 2017.pii: e30872. doi: 10.7554/eLife.30872.PMCID: PMC5653234
Langeberg, L.K. and Scott, J.D. (2015) Signalling scaffolds and local organization of cellular behaviour. Nature Reviews Molecular Cell Biology. 16:232-244. PMCID: PMC4722875