PEOPLE > John D. Scott, Ph.D.

John D. Scott, Ph.D.

Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology at the Howard Hughes Medical Institute;
Chair, Department of Pharmacology at University of Washington;
Professor, Pharmacology;
Professor and Chair, Provost, School of Medicine

Education and Training

Research Interests

John Scott is interested in the specificity of signal transduction events that are controlled by anchoring proteins, which facilitate rapid signal transduction by optimally positioning protein kinases and phosphatases in the vicinity of their activating signals and close to their substrates.

SELECTED PUBLICATIONS

Whiting, J.L., Ogier, L., Forbush, K., Bucko, P., Gopalan, J., Seternes, O.M., Langeberg, L.K., and Scott, J.D. (2016) AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Proc Natl Acad Sci U S A. 113:E4328-E4337. PMCID: PMC4968721.

Smith, F.D., Esseltine, J.L., Nygren, P.J., Vessler, D., Byrne, D.P., Vonderach, M., Strashnov, I., Eyers, C.E., Eyers, P.A., Langeberg, L.K., and Scott, J.D. (2017) Local protein kinase A action proceeds through intact holoenzymes. Science. 356:1288-1293. PMCID: PMC5693252

Nygren, P.J., Mehta, S., Schweppe, D.K., Langeberg, L.K., Whiting, J.L., Weisbrod, C.R., Bruce, J.E., Zhang, J., Veesler, D., and Scott, J.D. (2017) Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. eLife. 6:e30872 doi: 10.7554/eLife.30872 epub AOP Oct 2, 2017.pii: e30872. doi: 10.7554/eLife.30872.PMCID: PMC5653234

Langeberg, L.K. and Scott, J.D. (2015) Signalling scaffolds and local organization of cellular behaviour. Nature Reviews Molecular Cell Biology. 16:232-244. PMCID: PMC4722875