PEOPLE > Eric G. Neilson, M.D.

Eric G. Neilson, M.D.

Vice President for Medical Affairs
Landsberg Dean of Northwestern University Feinberg School of Medicine
Editor-in-Chief, Journal of American Society of Nephrology

Education and Training

Research Interests

The principal goal of my research is to understand the nephritogenic immune response in autoimmune renal disease. This research runs the gamut of immunologic mechanisms to understanding the development or organ fibrogenesis and cellular transdifferentiation. Our studies critically analyze the immunogenetic and interactional events surrounding T cell activation, effector T cell differentiation, immune modulation of renal tubular cells and fibroblasts in anti-basement membrane diseases, and with this understanding, develop experimental strategies which can attenuate the expression of renal injury. We have a particularly active interest in the cell fate of fibroblasts during fibrogenesis in transgenic mice. More recently we have gotten interested in how breast cancer cells use the same programs when they metastasize. We use trangenic and knockin mice, cell sorting, biochemical methosds of protein identification, molecular cloning and mutagenesis, as well as cell culture and confocal microscopy. (from Northwestern University)

SELECTED PUBLICATIONS

Web surveillance for CKD. Neilson EG. Journal of the American Society of Nephrology. 2013 Dec 28;24(1):1-3.doi:10.1681/ASN.2012111098. PMID: 23222125 PMCID: PMC3736699 ISSN: 10466673

Dogs don't bark at parked cars. Neilson EG. Journal of the American Society of Nephrology. 2013 May 31;24(6):863-.doi:10.1681/ASN.2013030324. PMID: 23729694 ISSN: 10466673

EGFR signaling promotes TGFβ-dependent renal fibrosis. Chen J, Chen J-K, Nagai K, Plieth D, Tan M, Lee T-C, Threadgill DW, Neilson EG, Harris RC. Journal of the American Society of Nephrology. 2012 Feb;23(2):215-224.doi:10.1681/ASN.2011070645. PMID: 22095949 PMCID: PMC3269185 ISSN: 10466673

Heart repair by reprogramming non-myocytes with cardiac transcription factors. Song K, Nam Y-J, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN. Nature. 2012 Jan;485(7400):599-604.doi:10.1038/nature11139. PMID: 22660318 PMCID: PMC3367390 ISSN: 00280836