RBK: Rebuilding a Kidney
Investigator
What is the Study?
Rebuilding the Glomerular Filtration Barrier by Regenerating Adult Podocytes
Podocytes are cells in the kidney’s glomerular filtering units that limit the passage of proteins from the blood into the urine. As adults, they cannot proliferate to replace themselves, and therefore, they are reliant on other stem cells for their regeneration
This project aims to rebuild kidney glomeruli by regenerating podocytes, terminally differentiated cells in the kidney glomerular filtering units that limit the passage of proteins from the blood into the urine, from two candidate resident stem/progenitor cells, cells of renin lineage (CoRL) and parietal epithelial cells (PECs).
Cell-specific delivery of novel therapies to enhance glomerular regeneration and repair
The goal of this project is to change the treatment paradigm for diseases affecting the podocytes, cells that physically filter the blood to form the urine, by combining therapeutics development with cell-specific delivery to enhance the natural ability of the body to repair and regenerate these highly specialized cells.
Who do I contact for more information?
Principal Investigator
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