Kidney Precision Medicine Project

The Kidney Precision Medicine Project (KPMP) is an ambitious, multi-year project funded by the NIDDK with the purpose of understanding and finding new ways to treat chronic kidney disease (CKD) and acute kidney injury (AKI).


Acute kidney injury (AKI) and chronic kidney disease (CKD) impose a significant global health burden. Yet, no effective therapies currently exist for AKI, and only a few are available for CKD. Historically, AKI and CKD have been described as single, uniform diseases. However, growing consensus suggests that different disease pathways lead to different subgroups of AKI and CKD (AKIs and CKDs).

Access to human kidney biopsy tissue is a critical first step to define disease heterogeneity and determine the precise molecular pathways that will facilitate identification of specific drug targets and ultimately enable individualized care for people with AKI and CKD.

KRI Director Jonathan Himmelfarb serves as contact PI for the multi-PI Central Hub. The Kidney Research Institute serves as the Administrative Core (AC) of the Central Hub, with Jonathan Himmelfarb and Ian de Boer serving as co-directors of the core. Responsibilities of the AC include, Administrative and meeting support, Establishing working groups and consortium organization, Ensuring patient input is requested, received, and implemented, Managing the Opportunity Pool to form new partnerships