STUDIES

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Study TitleRandomized Controlled Trial of Vitamin D3 in Diabetic Kidney Disease
Principal InvestigatorIan de Boer
Funding AgencyUW Institute for Translational Health Science (KL2), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/National Institutes of Health
Description

This study will assess the effects of vitamin D3 supplementation (cholecalciferol; 2000 IU daily) on serum calcium levels, circulating vitamin D levels, and markers of kidney disease and cardiovascular risk among people with diabetes mellitus and early kidney disease.

Study TitleChronic Kidney Disease in Disadvantaged Populations
Principal InvestigatorYoshio Hall
Funding Agency(1K23DK087900) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/National Institutes of Health
Description

This study will examine the prevalence of reduced kidney function among outpatient users of the health care safety-net and focus on studying their associated patterns of health services utilization. We anticipate that our research will form the basis for patient-centered interventions to improve the delivery of CKD care to diverse populations.

Study TitleHemodialysis Fistula Maturation Consortium (HFMC) Study
Principal InvestigatorJonathan Himmelfarb
Funding Agency(1U01DK082179) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/National Institutes of Health
Description

The HFMC is a prospective cohort study in six sites nationwide, to observe 600 individuals in whom a native fistula has been created for hemodialysis access. This study will identify predictors of clinical and physiological fistula maturation outcomes through standardized collection of data concerning vascular anatomy, vascular biology, clinical patient-level attributes, and processes of care.

Study TitleKidney Research Institute Study Registry
Principal InvestigatorJonathan Himmelfarb
Funding AgencyKidney Research Institute
Description

The purpose of this registry is to:
1). Maintain a list of potential subjects and their contact information
2). Maintain medical information to determine eligibility for specific projects, and
3). Facilitate querying information in order to determine if there are an adequate number of subjects for a specific study.

Study TitleKidney Research Institute Data and Biosample Repository: A Repository for Future Research in Kidney Disease
Principal InvestigatorJonathan Himmelfarb
Funding AgencyKidney Research Institute
Description

The purpose of the KRI repository is to use the banked data and specimens for the study of kidney disease. This includes conditions which may cause kidney disease (such as diabetes and hypertension), or resulting from kidney disease (such as cardiovascular disease, fractures, infections and diminished physical and mental functioning).

Study TitleEPO Dosing for Anemia in End Stage Renal Disease (EDEN)
Principal InvestigatorJonathan Himmelfarb
Funding Agency(R01DK091584) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/National Institutes of Health
Description

Our data suggests that the abundances of specific serum proteins and protein fragments (peptides) correlate with both an EPO good- and poor-response in ESRD patients. In preliminary studies these candidates classify EPO response with more sensitivity and specificity than other markers, like C-reactive protein and hepcidin.  We hypothesize that specific serum proteins and peptides are candidate surrogate biomarkers for EPO responsiveness and can be used to improve existing algorithms for predictive EPO response indexing

Study TitleEndothelial dysfunction nitric oxide and renal failure
Principal InvestigatorJonathan Himmelfarb
Funding Agency(R01HL065193) National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health
Description

The purpose of the study is to test the hypothesis that angiotensin-converting enzyme inhibition and angiotensin receptor blockade differ in their long term effects on biomarkers of fibrinolysis, oxidative stress,inflammation and on carotid intima-media thickness (IMT), a predictor of cardiovascular events, in patients with chronic kidney disease undergoing maintenance hemodialysis.

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