PEOPLE > Cecilia M. Giachelli, Ph.D.

Cecilia M. Giachelli, Ph.D.

Professor of Bioengineering, Adjunct Professor of Oral Biology and Pathology

Dept. of Bioengineering
University of Washington
Box 355061
William H. Foege Building
Room N330L
Seattle, WA 98195

P: (206) 543-0205

F: (206) 616-9763

E: ceci@uw.edu

Education and Training

Ph.D., Pharmacology
University of Washington
Seattle, WA

Pathology Fellowship
University of Washington School of Medicine
Seattle, WA

Research Interests

Dr. Giachelli is internationally recognized for her work investigating the molecular mechanisms of vascular calcification and extracellular matrix control of cell function. Her studies have led to the discovery of key inducers and inhibitors that contribute to vascular calcification in the setting of chronic kidney disease, atherosclerosis, medial arterial calcification and medical devices. These discoveries are currently being translated to therapeutic strategies to block and/or treat inappropriate calcification in disease and biomaterials development.

SELECTED PUBLICATIONS

Li X, Ying-Yang H, Giachelli CM. Role of the Sodium Dependent Phosphate Cotransporter, Pit-1, in Vascular Smooth Muscle Calcification. Circ Res. 98:905-12, 2006.

Speer MY, Yang HY, Look A, Frutkin A, Dichek D, Giachelli CM. Smooth Muscle Cells Give Rise to Osteochondrogenic Precursors and Chondrocytes in Calcifying Arteries, Circulation Research 104(6):733-41, 2009

El-Abbadi MM, Pai AS, Leaf EM, Yang HY, Bartley BA, Quan KK, Ingalls CM, Liao HW, Giachelli CM. Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin.Kidney Int. 75(12):1297-307, 2009.

Li X, Speer MY, Yang H, Bergen J, Giachelli CM. Vitamin D receptor activators induce an anticalcific paracrine program in macrophages: requirement of osteopontin. Arterioscler Thromb Vasc Biol. 30(2):321-6, 2010.

Festing MH, Speer MY, Yang HY, Giachelli CM. Generation of mouse conditional and null alleles of the type II sodium-dependent phosphate cotransporter PiT-1. Genesis. 47(12):858-63, 2009.